反应详情

Ethyl 1-benzyl-5-(1,3-dithiol-2-ylidene)-4,6-dioxopiperidine-3-carboxylate (2.0 g) is dissolved in ethanol (160 ml), and a 10% aqueous sodium hydroxide solution (8.0 ml) is added thereto. The mixture is refluxed for 2 hours. The mixture is cooled, neutralized with 10% hydrochloric acid, and then evaporated under reduced pressure to remove the solvent. The residue is dissolved in ethyl acetate, and the solution is washed with water, dried and then evaporated to remove the solvent. The residue thus obtained is recrystallized from isopropanol, whereby 1-benzyl-3-(1,3-dithiol-2-ylidene)-2,4-dioxopiperidine (1.26 g) is obtained as pale yellow needles. Yield: 78%.

1. temperatureThe mixture is refluxed for 2 hours
2. temperatureThe mixture is cooled
3. customevaporated under reduced pressure
4. customto remove the solvent
5. dissolutionThe residue is dissolved in ethyl acetate
6. washthe solution is washed with water
7. customdried
8. customevaporated
9. customto remove the solvent
10. customThe residue thus obtained
11. customis recrystallized from isopropanol