Dichloromethane → 3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

HRID 97796Notes

Reaction equation

HRID 97796 reaction equation
[Cl:32][CH2:33][Cl:34].[O:8]=[C:9]1[NH:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[CH2:17][CH:18]1[CH:19]1[CH2:20][CH2:21][N:22]([C:25]([O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[CH2:23][CH2:24]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[O:8]=[C:9]1[NH:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[CH2:17][CH:18]1[CH:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59731916tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)piperidine-1-carboxylate

Product 1

HCID 183212463-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one

Sources & evidence

ORD record
ord-e1a5ec88a5de42518de1fe53082a5fb2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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