Sodium Hydroxide → HCID 57016575, compound

HRID 977977Notes

Reaction equation

HRID 977977 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:19])[C:8]2[CH:16]=[C:15]([CH:17]=O)[S:14][C:9]=2[N:10]([CH2:12][CH3:13])[CH:11]=1)=[O:5])[CH3:2].Cl.[NH2:21][OH:22].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:19])[C:8]2[CH:16]=[C:15]([CH:17]=[N:21][OH:22])[S:14][C:9]=2[N:10]([CH2:12][CH3:13])[CH:11]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 13576752HCID 13576752, compound

Product 1

HCID 57016575HCID 57016575, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of warm ethanol was dissolved 0.5 g of 4,7-dihydro-7-ethyl-2-formyl-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester. The solution was cooled to room-temperature, then 0.2 g of hydroxylamine hydrochloride was added followed by 2 ml of a 5%-solution of sodium hydroxide. After filtration, 4,7-dihydro-7-ethyl-2-hydroxyiminomethyl-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester was obtained in a yield of 80%.

Workup

  1. temperatureThe solution was cooled to room-temperature
  2. filtrationAfter filtration

Sources & evidence

ORD record
ord-60b855d99f414cdebe0314ba938fb044
Source dataset
uspto-grants-1987_05
Patent number
US04663329

Reaction notes

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