Triethylamine → HCID 188931, compound

HRID 977998Notes

Reaction equation

HRID 977998 reaction equation
[CH3:1][N:2]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)[C:3](=[O:6])[CH:4]=[CH2:5].[CH3:15][C:16]([C:19]1[CH:24]=[C:23]([SH:25])[CH:22]=[C:21]([C:26]([CH3:29])([CH3:28])[CH3:27])[C:20]=1[OH:30])([CH3:18])[CH3:17].C(N(CC)CC)C>CO>[CH3:29][C:26]([C:21]1[CH:22]=[C:23]([S:25][CH2:5][CH2:4][C:3]([N:2]([CH3:1])[CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[O:6])[CH:24]=[C:19]([C:16]([CH3:18])([CH3:17])[CH3:15])[C:20]=1[OH:30])([CH3:27])[CH3:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 703702,6-Di-tert-butyl-4-mercaptophenolHCID 13822937HCID 13822937, compound

Product 1

HCID 188931HCID 188931, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-methyl-N-[2-(2-pyridinyl)ethyl]-2-propenamide (0.95 g, 0.005 mole) was dissolved in methanol (200 ml) containing 2,6-bis(1,1-dimethylethyl)-4-mercaptophenol (1.19 g, 0.005 mole). After addition of triethylamine (0.5 ml), the solution was stirred at room temperature overnight. The solvent was removed by a nitrogen stream to give a residue which was purified by chromatography on silica to give the title compound, m.p. ca. 82°-84° C.

Workup

  1. customThe solvent was removed by a nitrogen stream
  2. customto give a residue which
  3. customwas purified by chromatography on silica

Sources & evidence

ORD record
ord-c66f370a5424420d816c6626dc71872f
Source dataset
uspto-grants-1987_05
Patent number
US04663333

Reaction notes

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