1-(1H-Imidazol-1-yl)ethanone → HCID 13881151, compound

Participants

Reaction Steps

A 4.8 g (42.8 mmole) sample of 1-acetylimidazole was added to a solution of 5.14 g (20.8 mmole) of 1-[(1,1-dimethylethyl)amino]-3-(2-ethynylphenoxy)-2-propanol in 28 ml THF. The mixture was stirred under N2 for one hour. The mixture was partitioned between water and ether. The ether layer was washed with brine, dried (K2CO3) and the solvent evaporated in vacuo to give the title compound as an oil, 6.14 g.

Provenance & Evidence