1-(1H-Imidazol-1-yl)ethanone → HCID 13881151, compound

HRID 978011Notes

Reaction equation

HRID 978011 reaction equation
[C:1](N1C=CN=C1)(=[O:3])[CH3:2].[CH3:9][C:10]([NH:13][CH2:14][CH:15]([OH:26])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]#[CH:25])([CH3:12])[CH3:11]>C1COCC1>[C:1]([O:26][CH:15]([CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]#[CH:25])[CH2:14][NH:13][C:10]([CH3:9])([CH3:11])[CH3:12])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 13881152HCID 13881152, compound

Product 1

HCID 13881151HCID 13881151, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 4.8 g (42.8 mmole) sample of 1-acetylimidazole was added to a solution of 5.14 g (20.8 mmole) of 1-[(1,1-dimethylethyl)amino]-3-(2-ethynylphenoxy)-2-propanol in 28 ml THF. The mixture was stirred under N2 for one hour. The mixture was partitioned between water and ether. The ether layer was washed with brine, dried (K2CO3) and the solvent evaporated in vacuo to give the title compound as an oil, 6.14 g.

Workup

  1. customThe mixture was partitioned between water and ether
  2. washThe ether layer was washed with brine
  3. dry with materialdried (K2CO3)
  4. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-5382cf966208445181ad6cb3a52c0be1
Source dataset
uspto-grants-1987_05
Patent number
US04663334

Reaction notes

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