Hydrochloric Acid → HCID 178447643, compound

HRID 978038Notes

Reaction equation

HRID 978038 reaction equation
Cl.[CH3:2][N:3]1[C:7]([CH:8]([CH3:15])[CH2:9][CH2:10][C:11]([O:13]C)=[S:12])=[N:6][N:5]=[N:4]1>O>[CH3:2][N:3]1[C:7]([CH:8]([CH3:15])[CH2:9][CH2:10][C:11]([OH:13])=[S:12])=[N:6][N:5]=[N:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54172935Methyl 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiovalerate

Product 1

HCID 178447643HCID 178447643, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

20% aqueous Hydrochloric acid (150 ml) is added to methyl 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiovalerate (17 g) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with chloroform. The chlorofom solution is washed with aqueous saturated sodium chloride solution and dried over magnesium sulfate. Chloroform is distilled off to give 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-valeric acid, colorless liquid, nD26 =1.5133.

Workup

  1. temperaturethe mixture is refluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted with chloroform
  4. washThe chlorofom solution is washed with aqueous saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. distillationChloroform is distilled off

Sources & evidence

ORD record
ord-66a854a61ef94e1db8cb2e85e07aefe9
Source dataset
uspto-grants-1987_05
Patent number
US04663323

Reaction notes

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