Piperidine → HCID 13822956, compound

Participants

Reaction Steps

A stirred mixture of 7-methyl-7-azabicyclo[4.1.0]heptane (5.0 ml, 39 mmol), piperidine (3.9 ml, 39 mmol) and 0.2 g of ammonium chloride dissolved in 0.4 ml of water was heated under reflux for 5.5 hours. Normal work-up of the reaction mixture followed by bulb-to-bulb distillation yielded 3.2 g (42%) of trans-N-methyl-2-(1-piperidinyl)cyclohexanamine as a colorless liquid, bp 210° C. (at a pressure of 2666 Pascal).

Provenance & Evidence