Piperidine → HCID 13822956, compound

HRID 978067Notes

Reaction equation

HRID 978067 reaction equation
[CH3:1][N:2]1[CH:8]2[CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]2.[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.[Cl-].[NH4+]>O>[CH3:1][NH:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 25517Ammonium ChlorideHCID 12396089HCID 12396089, compound

Product 1

HCID 13822956HCID 13822956, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred mixture of 7-methyl-7-azabicyclo[4.1.0]heptane (5.0 ml, 39 mmol), piperidine (3.9 ml, 39 mmol) and 0.2 g of ammonium chloride dissolved in 0.4 ml of water was heated under reflux for 5.5 hours. Normal work-up of the reaction mixture followed by bulb-to-bulb distillation yielded 3.2 g (42%) of trans-N-methyl-2-(1-piperidinyl)cyclohexanamine as a colorless liquid, bp 210° C. (at a pressure of 2666 Pascal).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5.5 hours
  3. distillationNormal work-up of the reaction mixture followed by bulb-to-bulb distillation

Sources & evidence

ORD record
ord-79a5a617de6846a48fe10a42bfe4285e
Source dataset
uspto-grants-1987_05
Patent number
US04663343

Reaction notes

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