反应详情

A mixture of ethyl-4-hydroxy-3-methylbenzofuran-2-carboxylate (11.0 g, 50 mmol), allyl bromide (4.8 ml, 55 mmol) and potassium carbonate (55 mmol) was refluxed in acetone (300 ml) for 4 hours. The resulting mixture was cooled, filtered and concentrated. The residue was chromatographed (silica gel, eluted with 5% ethyl acetate in hexane) to give 12 g of the title compound, m.p. 64°-65° C.

1. temperatureThe resulting mixture was cooled
2. filtrationfiltered
3. concentrationconcentrated
4. customThe residue was chromatographed
5. wash(silica gel, eluted with 5% ethyl acetate in hexane)