Imidazole → 1H-Imidazole, 1-(1-oxohexyl)-

HRID 978337Notes

Reaction equation

HRID 978337 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[C:6](Cl)(=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>C1(C)C=CC=CC=1>[C:6]([N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)(=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 67340Hexanoyl chloride

Product 1

HCID 109208801H-Imidazole, 1-(1-oxohexyl)-

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The method of Pfander and Laederach [H. Pfander and M. Laederach, Carbohyd. Res. 99(2), 175-79 (1982)] was used. 1-Hexanoylimidazole was prepared by stirring 2 equivalents of imidazole with 1 equivalent hexanoyl chloride in toluene solution. The mixture was filtered and concentrated to a low-melting solid. This product, 1-hexanoylimidazole, was further purified by distillation.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated to a low-melting solid
  3. distillationThis product, 1-hexanoylimidazole, was further purified by distillation

Sources & evidence

ORD record
ord-a52b058a9a9f42f8b49af0aa6486c189
Source dataset
uspto-grants-1987_05
Patent number
US04665057

Reaction notes

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