Methylamine → HCID 13883781, compound

HRID 978369Notes

Reaction equation

HRID 978369 reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=O)[N:8]=1.[CH3:25][NH2:26]>CCO>[CH3:25][NH:26][C:17](=[O:19])[CH2:16][CH2:15][CH2:14][S:13][C:9]1[N:8]=[C:7]([NH:6][C:5]([NH2:22])=[N:4][CH2:3][C:2]([F:1])([F:23])[F:24])[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20202857HCID 20202857, compound

Product 1

HCID 13883781HCID 13883781, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 4-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-ylthio]butyrate (0.18 g.) and a 33% w/v solution of methylamine in EtOH (5 ml.) was stirred at room temperature for 4 days and then evaporated to dryness. The residue was recrystallised from EtOAc to give N-methyl-4-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-ylthio]butyramide (0.09 g.), m.p. 153°-155°.

Workup

  1. customevaporated to dryness
  2. customThe residue was recrystallised from EtOAc

Sources & evidence

ORD record
ord-b8e0cc47ef6d4a05ab531aa41cbb527a
Source dataset
uspto-grants-1987_05
Patent number
US04665073

Reaction notes

Loading…