Ammonia → HCID 20202857, compound

HRID 978371Notes

Reaction equation

HRID 978371 reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:8]=1.[NH3:25]>CN(C=O)C>[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20202782HCID 20202782, compound

Product 1

HCID 20202857HCID 20202857, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of ethyl 4-[4-(3-[2,2,2-trifluoroethyl]thioureido)pyrimid-2-ylthio]butyrate (0.25 g.), DMF (2 ml.), saturated ethanolic ammonia (5 ml.) and yellow mercuric oxide (0.2 g.) was stirred at room temperature for 2 hours and then filtered. The filtrate was evaporated to dryness and the residue recrystallised from EtOAc to give ethyl 4-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-ylthio]butyrate, m.p. 120°-122°.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness
  3. customthe residue recrystallised from EtOAc

Sources & evidence

ORD record
ord-309e57f9a43d489ab1daef3e5ce8a886
Source dataset
uspto-grants-1987_05
Patent number
US04665073

Reaction notes

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