HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Methyl-4-hydroxy-anilino-methyl-2-imidazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Amino-m-cresol | HCID 17819 | — |
| Reactant | 2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride | HCID 2760928 | — |
| Product | 2-Methyl-4-hydroxy-anilino-methyl-2-imidazoline hydrochloride | HCID 70432379 | — |
Reaction Steps
Two moles 4-amino-m-cresol and 1 mole 2-chloromethyl-2-imidazoline hydrochloride are refluxed for 3 hours, within absolute ethanol. After cooling, the insoluble fraction is suction filtered and the ethanol solution is evaporated in vacuo. The evaporation residue is recrystallized from methanol:diethyl ether; M.p.=205°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04665085 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-04ce3127cf734f41816f9b8cfdd3b5c6 |
| Source note | uspto-grants-1987_05 |