反应详情

A mixture of 5 parts of 4-chlorobutanenitrile, 10 parts of (4-fluorophenyl)(4-piperidinyl)methanone, 10 parts of sodium carbonate and 200 parts of 4-methyl-2-pentanone was stirred and refluxed overnight. The reaction mixture was filtered and the filtrate was evaporated. The oily residue was crystallized from 2,2'-oxybispropane. The product was filtered off and recrystallized from 2,2'-oxybispropane, yielding 6.1 parts of 4-(4-fluorobenzoyl)-1-piperidinebutanenitrile; mp. 100° C. (5).

1. temperaturerefluxed overnight
2. filtrationThe reaction mixture was filtered
3. customthe filtrate was evaporated
4. customThe oily residue was crystallized from 2,2'-oxybispropane
5. filtrationThe product was filtered off
6. customrecrystallized from 2,2'-oxybispropane