Ammonia → HCID 20202880, compound

HRID 978440Notes

Reaction equation

HRID 978440 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][C:22]#[N:23])[CH2:15][CH2:14]3)[O:12][CH2:11][CH2:10][O:9]2)=[CH:4][CH:3]=1.N.[H][H].C[OH:28]>[Ni]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH:13]3[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH2:21][C:22]([NH2:23])=[O:28])[CH2:17][CH2:18]3)[O:9][CH2:10][CH2:11][O:12]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 887MethanolHCID 20202878HCID 20202878, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20202880HCID 20202880, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

A mixture of 28 parts of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidinebutanenitrile and 200 parts of methanol saturated with ammonia was hydrogenated at normal pressure and at room temperature with 5 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over Hyflo and the filtrate was evaporated, yielding 25 parts (95%) of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidinebutanamide as a residue (10).

Workup

  1. filtrationthe catalyst was filtered off over Hyflo
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-a5d59c5c19d64c8f9f0ac3bdcb8de0af
Source dataset
uspto-grants-1987_05
Patent number
US04665075

Reaction notes

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