Ammonia → HCID 20202880, compound

Participants

Reaction Steps

A mixture of 28 parts of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidinebutanenitrile and 200 parts of methanol saturated with ammonia was hydrogenated at normal pressure and at room temperature with 5 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over Hyflo and the filtrate was evaporated, yielding 25 parts (95%) of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidinebutanamide as a residue (10).

Provenance & Evidence