2-Fluorobenzoyl chloride → HCID 20203316, compound

Participants

Reaction Steps

To a stirred mixture of 30.3 g (0.363 moles) methoxyamine hydrochloride and 51 g (0.37 moles) potassium carbonate in about 300 ml water/methylene chloride maintained at a temperature below -5° C., 50 g (0.32 moles) 2-fluoro-benzoylchloride were dropped in. The reaction mixture was then allowed to stir at room temperature overnight. The aqueous and methylene chloride layers were separated. The methylene chloride layer was dried over magnesium sulfate, filtered and stripped to give about 45 g of the above-identified product, as a clear amber liquid.

Provenance & Evidence