2-Fluorobenzoyl chloride → HCID 20203316, compound

HRID 978469Notes

Reaction equation

HRID 978469 reaction equation
Cl.[CH3:2][O:3][NH2:4].C(=O)([O-])[O-:6].[K+].[K+].[F:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>O.C(Cl)Cl>[CH3:2][O:3][N:4]([C:14](=[O:15])[C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=1[F:11])[OH:6]

Participants

5

Reactant 3

HCID 98082-Fluorobenzoyl chlorideHCID 11430Potassium CarbonateHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 20203316HCID 20203316, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 21908982Water methylene chlorideSolvent

Procedure

To a stirred mixture of 30.3 g (0.363 moles) methoxyamine hydrochloride and 51 g (0.37 moles) potassium carbonate in about 300 ml water/methylene chloride maintained at a temperature below -5° C., 50 g (0.32 moles) 2-fluoro-benzoylchloride were dropped in. The reaction mixture was then allowed to stir at room temperature overnight. The aqueous and methylene chloride layers were separated. The methylene chloride layer was dried over magnesium sulfate, filtered and stripped to give about 45 g of the above-identified product, as a clear amber liquid.

Workup

  1. additionwere dropped in
  2. customThe aqueous and methylene chloride layers were separated
  3. dry with materialThe methylene chloride layer was dried over magnesium sulfate
  4. filtrationfiltered

Sources & evidence

ORD record
ord-8b96be3d506843f9871ffc64cc9575e6
Source dataset
uspto-grants-1987_05
Patent number
US04665093

Reaction notes

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