huagongshe.com
HRID978495

反应详情

EQUATION

反应方程式

HRID 978495 反应方程式

REACTANTS

反应物

3
1,8-Diazabicyclo[5.4.0]undec-7-ene 分子结构式
HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 分子结构式
HCID9835179

1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C12H8F3NO3

N-[(Pyrrolidin-3-yl)methyl]ethanamine 分子结构式
HCID13491786

N-[(Pyrrolidin-3-yl)methyl]ethanamine

C7H16N2

PRODUCTS

产物

1
6,8-Difluoro-4-hydroxy-3-quinolinecarboxylic acid 分子结构式
HCID5107860

6,8-Difluoro-4-hydroxy-3-quinolinecarboxylic acid

C10H5F2NO3

AUXILIARIES

试剂、催化剂与溶剂

1
Acetonitrile 分子结构式
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A mixture of 22.50 g (83.03 mmole) 1-ethyl-1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylic acid, 225 ml acetonitrile, 11.25 g (87.08 mmole) N-ethyl-3-pyrrolidinemethanamine and 12.6 g (83.03 mmole) 1,8-diazabicyclo[5.4.0]undec-7-ene was refluxed 1 hour then was stirred at room temperature overnight. The solid was filtered and washed with ether to give 26.33 g of 1-ethyl-7-[3-(ethylamino)-methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 208°-210° C.

WORKUP

后处理

  1. temperaturewas refluxed 1 hour
  2. filtrationThe solid was filtered
  3. washwashed with ether