Allylamine → HCID 13137238, compound

HRID 978610Notes

Reaction equation

HRID 978610 reaction equation
[CH2:1]([CH:3]1[CH:7](O)[CH:6]=[CH:5][C:4]1=[O:9])[CH3:2].[CH2:10]([NH2:13])[CH:11]=[CH2:12]>C1(C)C=CC=CC=1>[CH2:1]([C:3]1[C:4](=[O:9])[CH2:5][CH:6]([NH:13][CH2:10][CH:11]=[CH2:12])[CH:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 7853AllylamineHCID 13037816HCID 13037816, compound

Product 1

HCID 13137238HCID 13137238, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Ethyl-3-hydroxy-4-cyclopentenone (12.6 g) was dropwise added to a mixture of allylamine (25 g) and toluene (25 g) in the same flask as used in Example 1 at a temperature of 10° to 20° C. for 1 hour. The reaction mixture was kept at a temperature of 20° to 30° C. for 3 hours. After completion of the reaction, the mixture was treated and purified in the same manner as in Example 1 to obtain 2-ethyl-4-allylamino-2-cyclopentenone (15.7 g). Yield, 95%. nD20 1.4924.

Workup

  1. waitThe reaction mixture was kept at a temperature of 20° to 30° C. for 3 hours
  2. customAfter completion of the reaction
  3. additionthe mixture was treated
  4. custompurified in the same manner as in Example 1

Sources & evidence

ORD record
ord-e6a588ea82144b9b82ac075d106146a0
Source dataset
uspto-grants-1987_05
Patent number
US04665174

Reaction notes

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