反应详情

温度

100 °C

36 g of sodium 2-chloro-5-nitrobenzenesulphinate, 12.6 g of solid sodium hydrogen carbonate and 22.5 g of maleic anhydride are heated at 100° C. in 250 ml of water for 3 hours. After cooling down, a further 12.6 g of sodium hydrogencarbonate and 22.5 g of maleic anhydride are then added. After a further 5 hours of stirring at 100° C., the cooled, weakly acid reaction mixture is filtered with suction. The filter is cake at 50° C. in 300 ml of water, and the suspension is cooled down to 20° C. and is filtered again with suction. Drying gives 35.1 g of 3-(2-chloro-5-nitrophenylsulphonyl)-propionic acid.

1. temperatureAfter cooling down
2. customthe cooled, weakly acid reaction mixture
3. filtrationis filtered with suction
4. customat 50° C.
5. temperaturethe suspension is cooled down to 20° C.
6. filtrationis filtered again with suction
7. customDrying