Hydrochloric Acid → HCID 135626456, compound

Participants

Reaction Steps

A mixture of 2-amino-7,8-dihydro-6-methoxymethyl-7,7-dimethyl-4(3H)-pteridinone, 0.10 g and platinum oxide (prereduced) 0.015 g, in 6 mL of 2N HCl was hydrogenated at 1 atm H2 at room temperature for 2.5 hr. the mixture was filtered, and the filtrate was evaporated. This crude product was recrystallized from 6N HCl/MeCN to yield 2-amino-5,6,7,8-tetrahydro-6-methoxymethyl-7,7-dimethyl-4(3H)-pteridinone hydrochloride 0.089 g as a white solid, m.p. 214°-300° C. (dec), 76% of theoretical yield.

Provenance & Evidence