Hydrochloric Acid → HCID 135626456, compound

HRID 978640Notes

Reaction equation

HRID 978640 reaction equation
[NH2:1][C:2]1[NH:11][C:10](=[O:12])[C:9]2[N:8]=[C:7]([CH2:13][O:14][CH3:15])[C:6]([CH3:17])([CH3:16])[NH:5][C:4]=2[N:3]=1.[ClH:18]>[Pt]=O>[ClH:18].[NH2:1][C:2]1[NH:11][C:10](=[O:12])[C:9]2[NH:8][CH:7]([CH2:13][O:14][CH3:15])[C:6]([CH3:17])([CH3:16])[NH:5][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 135626462HCID 135626462, compound

Product 1

HCID 135626456HCID 135626456, compound

Reagents, catalysts & solvents 1

HCID 82844Platinum oxide (PtO)Catalyst

Procedure

A mixture of 2-amino-7,8-dihydro-6-methoxymethyl-7,7-dimethyl-4(3H)-pteridinone, 0.10 g and platinum oxide (prereduced) 0.015 g, in 6 mL of 2N HCl was hydrogenated at 1 atm H2 at room temperature for 2.5 hr. the mixture was filtered, and the filtrate was evaporated. This crude product was recrystallized from 6N HCl/MeCN to yield 2-amino-5,6,7,8-tetrahydro-6-methoxymethyl-7,7-dimethyl-4(3H)-pteridinone hydrochloride 0.089 g as a white solid, m.p. 214°-300° C. (dec), 76% of theoretical yield.

Workup

  1. filtrationthe mixture was filtered
  2. customthe filtrate was evaporated
  3. customThis crude product was recrystallized from 6N HCl/MeCN

Sources & evidence

ORD record
ord-65de44c3ce044b5f8da31d9148911a93
Source dataset
uspto-grants-1987_05
Patent number
US04665182

Reaction notes

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