Hydrochloric Acid → HCID 13607600, compound

HRID 978775Notes

Reaction equation

HRID 978775 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH:8]2[CH2:17][CH2:16][C:15]3[CH:14]=[C:13]([C:18]([O:20]CC)=[O:19])[CH:12]=[CH:11][C:10]=3[CH2:9]2)[CH:2]=1.[ClH:23]>>[ClH:23].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH:8]2[CH2:17][CH2:16][C:15]3[CH:14]=[C:13]([C:18]([OH:20])=[O:19])[CH:12]=[CH:11][C:10]=3[CH2:9]2)[CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21289505HCID 21289505, compound

Product 1

HCID 13607600HCID 13607600, compound

Procedure

1.8 g of ethyl 6-(3-pyridylmethyl)-5,6,7,8-tetrahydro-2-naphthalenecarboxylate was mixed with 50 ml of 6 normal hydrochloric acid and the mixture was heated under reflux for 4 hours. The reaction mixture was concentrated to dryness in vacuo. The residue was recrystallized from methanol to give 1.04 g of 6-(3-pyridylmethyl)-5,6,7,8-tetrahydro-2-naphthalenecarboxylic acid hydrochloride as colorless crystals with m.p. 222°-226° C.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. concentrationThe reaction mixture was concentrated to dryness in vacuo
  4. customThe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-caea4e599efa48fc971eb7141cf3d1e5
Source dataset
uspto-grants-1987_05
Patent number
US04665188

Reaction notes

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