4'-Hydroxyacetophenone → HCID 178465686, compound

HRID 978792Notes

Reaction equation

HRID 978792 reaction equation
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=O.P(O)(O)(O)=O.[NH2:16][OH:17].[OH-].[NH4+]>O>[CH3:1][C:2]([NH:16][OH:17])=[C:4]1[CH:5]=[CH:6][C:7](=[O:10])[CH:8]=[CH:9]1

Participants

5

Reactant 3

HCID 74694'-HydroxyacetophenoneHCID 14923Ammonium HydroxideHCID 167787Hydroxylamine dihydrogen phosphate

Product 1

HCID 178465686HCID 178465686, compoundYield 211.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution was prepared by adding 20.4 g (0.15 mol) of 4-hydroxyacetophenone and 12.9 g (65.6 mmol) of hydroxylamine phosphate to 100 mL of water at 70° C. To the solution was added 16.3 mL of 30% ammonium hydroxide which was then heated at reflux for 0.5 h. White crystals formed upon cooling yielding 21.0 g (92.6%) of 4-hydroxyacetophenone oxime.

Workup

  1. customA solution was prepared
  2. temperaturewas then heated
  3. temperatureat reflux for 0.5 h
  4. customWhite crystals formed
  5. temperatureupon cooling

Sources & evidence

ORD record
ord-165f0e11e652467cace58c9357e430b8
Source dataset
uspto-grants-1987_05
Patent number
US04665216

Reaction notes

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