反应详情

160 g (1.0 mol) of hydroxymethylenemalonic acid dimethyl ester is dissolved in 288 g (9.0 mol) of methanol and 50 g of hydrogen chloride gas is introduced. Then 55.2 g (1.35 mol) of acetonitrile is added and the mixture is let stand for 24 hours at room temperature. Then the low-boiling substances are distilled out, dichloromethane is added to the residue, and ammonium chloride is filtered out. The filtrate is treated with 1.6 g of potassium bisulfate and heated while distilling the volatile components up to 130° C. 138 g (0.79 mol) of methoxymethylenmalonic acid dimethyl ester is obtained, corresponding to 79.3% of the theory.

1. distillationThen the low-boiling substances are distilled out
2. additiondichloromethane is added to the residue, and ammonium chloride
3. filtrationis filtered out
4. additionThe filtrate is treated with 1.6 g of potassium bisulfate
5. temperatureheated
6. distillationwhile distilling the volatile components up to 130° C