Water → 5-[2-(5-Chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyridin-2-ylamine
Reaction equation
[C:30](=[O:31])([O-:32])[O-:33].[Cl:36][CH2:37][Cl:38].[Cl:9][c:10]1[cH:11][cH:12][c:13]([F:29])[c:14](-[c:16]2[n:17][c:18]3[n:19][cH:20][cH:21][cH:22][c:23]3[c:24]([B:26]([OH:27])[OH:28])[cH:25]2)[cH:15]1.[Cs+:34].[Cs+:35].[NH2:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1.[O:39]1[CH2:40][CH2:41][O:42][CH2:43][CH2:44]1.[OH2:45].[Pd:46].[c:104]1([P:105]([c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)[cH:118][cH:119][cH:120][cH:121][cH:122]1.[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1.[c:66]1([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[cH:80][cH:81][cH:82][cH:83][cH:84]1.[c:85]1([P:86]([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[cH:99][cH:100][cH:101][cH:102][cH:103]1>>[NH2:1][c:2]1[n:3][cH:4][c:5](-[c:24]2[c:23]3[c:18]([n:17][c:16](-[c:14]4[c:13]([F:29])[cH:12][cH:11][c:10]([Cl:9])[cH:15]4)[cH:25]2)[n:19][cH:20][cH:21][cH:22]3)[cH:6][cH:7]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-4692d8cd966b4c4e8702c452c861125e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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