Potassium Hydroxide → (1-Methyl-1-ethylpropylamino)ethoxyethanol

HRID 978816Notes

Reaction equation

HRID 978816 reaction equation
[CH3:1][C:2]([NH2:7])([CH2:5][CH3:6])[CH2:3][CH3:4].Cl[CH2:9][CH2:10][O:11][CH:12]([OH:14])[CH3:13].[OH-].[K+]>COCCO>[CH3:1][C:2]([NH:7][CH2:9][CH2:10][O:11][CH:12]([OH:14])[CH3:13])([CH2:5][CH3:6])[CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 43396263-Methylpentan-3-amineHCID 221454452-Chloroethoxyethanol

Product 1

HCID 86739621(1-Methyl-1-ethylpropylamino)ethoxyethanol

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A solution of 124.7 g of 1-methyl-1-ethylpropylamine and 76.9 g of 2-chloroethoxyethanol in 300 ml of ethylene glycol monomethylether was refluxed overnight. The reaction mixture was treated with a stoichiometric excess of KOH and refluxed for one hour, filtered, and distilled. The product had a b.p. of 153° C. (2 mm). Analysis calculated for C10H23NO2 :% N, 7.4, found %N, 7.15.

Workup

  1. temperaturerefluxed for one hour
  2. filtrationfiltered
  3. distillationdistilled

Sources & evidence

ORD record
ord-e8016256d9004eda802daf757106c1d7
Source dataset
uspto-grants-1987_05
Patent number
US04665234

Reaction notes

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