Sulfuryl chloride → 2-Chloro-N-(5-chloro-2,4-dimethylthiophen-3-yl)acetamide

HRID 978930Notes

Reaction equation

HRID 978930 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:12])[C:6]=1[NH:7][C:8](=[O:11])[CH2:9][Cl:10].S(Cl)([Cl:16])(=O)=O>C(Cl)Cl>[Cl:16][C:4]1[S:3][C:2]([CH3:1])=[C:6]([NH:7][C:8](=[O:11])[CH2:9][Cl:10])[C:5]=1[CH3:12]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 20201107N-(2,4-Dimethylthien-3-yl)-chloroacetamide

Product 1

HCID 202010952-Chloro-N-(5-chloro-2,4-dimethylthiophen-3-yl)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the stirred solution of 5.0 g (0.0245 mol) of N-(2,4-dimethylthien-3-yl)-chloroacetamide in 50 ml of dry CH2Cl2 are added dropwise at 0° 3.3 g (0.0245 mol) of sulfuryl chloride.

Sources & evidence

ORD record
ord-32dca15284224d2a95fe9600b582abdb
Source dataset
uspto-grants-1987_05
Patent number
US04666502

Reaction notes

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