Acetic Acid → HCID 135626420, compound

HRID 979032Notes

Reaction equation

HRID 979032 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2OC(=O)[C:12](=[C:16]=[O:17])[CH2:11]2)=[CH:2]1.O.[NH2:19][NH2:20].[C:21]([OH:24])(=O)C>COCCO>[OH:24][CH2:21][CH:11]1[C:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)=[N:20][NH:19][C:16](=[O:17])[CH2:12]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24654Hydrazine hydrate (1:1)HCID 86741513HCID 86741513, compound

Product 1

HCID 135626420HCID 135626420, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

3.3 g (b 0.014 mol) of 4-(3-indolyl)-carbonyl-γ-butyrolactone and 0.85 ml (0.018 mol) of hydrazine hydrate are stirred in 50 ml of ethylene glycol monomethyl ether and 1 ml of acetic acid at 80° C. for 18 hours. After 10 ml of petroleum ether have been added to the reaction mixture, the product crystallises with a good purity.

Workup

  1. customthe product crystallises with a good purity

Sources & evidence

ORD record
ord-37ced8474abc4dc1a90d0c8fdf15d3e6
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

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