Ethanol → HCID 11820427, compound

HRID 979034Notes

Reaction equation

HRID 979034 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH:8]1OC(=O)[CH2:10][CH2:9]1)=O.[OH2:14].[NH2:15][NH2:16].[CH2:17]([OH:19])C>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:8]([CH2:17][OH:19])[CH2:9][C:10](=[O:14])[NH:15][N:16]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 16107648HCID 16107648, compound

Product 1

HCID 11820427HCID 11820427, compound

Procedure

11.8 g (0.06 mol) of 4-(2-thienyl-carbonyl)-γ-butyrolactone and 3.1 g (0.062 mol) of hydrazine hydrate are stirred in 100 ml of ethanol at room temperature for 2 hours. The precipitated hydrazone is filtered off with suction, 60 ml of toluene and 6 ml of acetic acid are added and the mixture is heated under reflux for 2 hours. After the mixture has been cooled, the precipitated product is filtered off with suction, washed and dried.

Workup

  1. filtrationThe precipitated hydrazone is filtered off with suction, 60 ml of toluene and 6 ml of acetic acid
  2. additionare added
  3. temperaturethe mixture is heated
  4. temperatureunder reflux for 2 hours
  5. temperatureAfter the mixture has been cooled
  6. filtrationthe precipitated product is filtered off with suction
  7. washwashed
  8. customdried

Sources & evidence

ORD record
ord-6ba4dbd5e5544135ba07533078f017a0
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

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