Ethanol → HCID 13576365, compound

HRID 979036Notes

Reaction equation

HRID 979036 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([CH:15]3OC(=O)[CH2:17][CH2:16]3)=O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[OH2:21].[NH2:22][NH2:23].[CH2:24]([OH:26])C>>[N:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:13]3[CH:15]([CH2:24][OH:26])[CH2:16][C:17](=[O:21])[NH:22][N:23]=3)=[CH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][C:2]1=[O:6]

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 20201463HCID 20201463, compound

Product 1

HCID 13576365HCID 13576365, compound

Procedure

8.4 g (0.031 mol) of 4-(4-(1-pyrrolidin-2-onyl)-phenyl-carbonyl)-γ-butyrolactone and 1.7 g (0.034 mol) of hydrazine hydrate are stirred in 50 ml of ethanol at 50° C. for 2 hours, the mixture is cooled and the precipitate is filtered off with suction. The resulting hydrazone is heated under reflux with 70 ml of ethanol and 5 ml of acetic acid for 2 hours, the mixture is cooled and the precipitate is filtered off with suction and dried.

Workup

  1. temperaturethe mixture is cooled
  2. filtrationthe precipitate is filtered off with suction
  3. temperatureThe resulting hydrazone is heated
  4. temperatureunder reflux with 70 ml of ethanol and 5 ml of acetic acid for 2 hours
  5. temperaturethe mixture is cooled
  6. filtrationthe precipitate is filtered off with suction
  7. customdried

Sources & evidence

ORD record
ord-24380a115d35484a8583e80d37fe8b13
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

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