Acetic Acid → HCID 13576375, compound

HRID 979043Notes

Reaction equation

HRID 979043 reaction equation
O.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:14]2[O:18][C:17](=[N:19][NH2:20])[C:16](=C=O)[CH2:15]2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11].[C:23](O)(=[O:25])C>CN(C)C=O>[OH:25][CH2:23][CH:15]1[C:14]([C:6]2[CH:7]=[C:8]([O:12][CH3:13])[C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=2)=[N:20][NH:19][C:17](=[O:18])[CH2:16]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 86741519HCID 86741519, compound

Product 1

HCID 13576375HCID 13576375, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7.0 g (0.222 mol) of the compound prepared in section (a) are stirred in 20 ml of dimethylformamide and 1 ml of acetic acid at 80° C. for 5 hours. After the mixture has been concentrated, the residue is taken up in methylene chloride, the methylene chloride mixture is washed with potassium carbonate solution and concentrated and the residue is recrystallised from ethanol.

Workup

  1. concentrationAfter the mixture has been concentrated
  2. washthe methylene chloride mixture is washed with potassium carbonate solution
  3. concentrationconcentrated
  4. customthe residue is recrystallised from ethanol

Sources & evidence

ORD record
ord-a67bc207600646b6b088306e732fc926
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

Loading…