反应详情

Into 40 ml of dichloromethane, was dissolved 6.5 g of 1-phenylpiperazine. To the solution, while being stirred and cooled in ice, was added dropwise 3.0 g of 2,4-dimethylallophanoyl chloride. After 0.5 hour of reaction at room temperature, the reaction mixture was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation and the residue was recrystallized from a mixture of ethanol and petroleum ether to obtain 4.0 g (72% yield) of 1-(2,4-dimethyl-allophanoyl)-4-phenylpiperazine having a melting point of 79°-80° C.

1. temperaturecooled in ice
2. customAfter 0.5 hour of reaction at room temperature
3. washthe reaction mixture was washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed by distillation
6. customthe residue was recrystallized from a mixture of ethanol and petroleum ether