Hydrochloric Acid → 2-Amino-5-methoxybenzene-1-thiol

Participants

Reaction Steps

To a stirred solution of 8N potassium hydroxide (1.3 l) was added 2-amino-6-methoxybenzothiazole (750 g) and the mixture was refluxed overnight. The resulting solution was neutralized by the addition of conc. HCl to pH 8.0, then acetic acid to pH 6.0. The precipitate which formed was filtered and washed with water to afford the title compound which was used immediately in Step 3.

Provenance & Evidence