Hydrochloric Acid → 2-Amino-5-methoxybenzene-1-thiol

HRID 979088Notes

Reaction equation

HRID 979088 reaction equation
[OH-].[K+].NC1[S:5][C:6]2[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:7]=2[N:8]=1.Cl>C(O)(=O)C>[NH2:8][C:7]1[CH:9]=[CH:10][C:11]([O:13][CH3:14])=[CH:12][C:6]=1[SH:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 156302-Amino-6-methoxybenzothiazole

Product 1

HCID 2355092-Amino-5-methoxybenzene-1-thiol

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a stirred solution of 8N potassium hydroxide (1.3 l) was added 2-amino-6-methoxybenzothiazole (750 g) and the mixture was refluxed overnight. The resulting solution was neutralized by the addition of conc. HCl to pH 8.0, then acetic acid to pH 6.0. The precipitate which formed was filtered and washed with water to afford the title compound which was used immediately in Step 3.

Workup

  1. temperaturethe mixture was refluxed overnight
  2. customThe precipitate which formed
  3. filtrationwas filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-3de854cf45154868909d695c85a3bc61
Source dataset
uspto-grants-1987_05
Patent number
US04666907

Reaction notes

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