Hydrochloric Acid → HCID 13882043, compound

HRID 979095Notes

Reaction equation

HRID 979095 reaction equation
[C:1]([N:4]1[C:17]2[CH:16]=[C:15]([O:18][CH3:19])[C:14]([O:20]C(=O)C)=[C:13]([Br:24])[C:12]=2[S:11][C:10]2[C:5]1=[CH:6][CH:7]=[C:8]([O:25][CH3:26])[CH:9]=2)(=[O:3])[CH3:2].Cl>CO.[OH-].[Na+]>[C:1]([N:4]1[C:17]2[CH:16]=[C:15]([O:18][CH3:19])[C:14]([OH:20])=[C:13]([Br:24])[C:12]=2[S:11][C:10]2[C:5]1=[CH:6][CH:7]=[C:8]([O:25][CH3:26])[CH:9]=2)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 13882042HCID 13882042, compound

Product 1

HCID 13882043HCID 13882043, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 10-acetyl-3-acetoxy-4-bromo-2,7-dimethoxy-10H-phenothiazine (2.0 g) in methanol (40 ml) and 1N aqueous sodium hydroxide solution (40 ml) was stirred at room temperature for 5 hours. The mixture was then made slightly acidic with 1N aqueous HCl and after 15 minutes the crude product was filtered. Crystallization from ethyl acetate afforded the pure title compund (600 mg), m.p.: dec 235° C.

Workup

  1. filtrationthe crude product was filtered
  2. customCrystallization from ethyl acetate
  3. customafforded the pure title compund (600 mg)
  4. custom235° C.

Sources & evidence

ORD record
ord-6dca9966b9e844c5ad86c7191ed208a8
Source dataset
uspto-grants-1987_05
Patent number
US04666907

Reaction notes

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