2-Butoxyaniline → Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate

HRID 979111노트

반응식

HRID 979111 반응식
CS[C:3]1[NH:4][C:5](=[O:14])[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][N:8]=1.[CH2:15]([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH2:22])[CH2:16][CH2:17][CH3:18]>N1C=CC=CC=1>[CH2:15]([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH:22][C:3]1[NH:4][C:5](=[O:14])[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][N:8]=1)[CH2:16][CH2:17][CH3:18]

참가 물질

4

반응물 2

HCID 1382652-ButoxyanilineHCID 239049Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate

생성물 1

HCID 13562779Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate수율 60.1%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (21.5 g) and 2-butoxyaniline (24 g) are added to pyridine (50 ml), and the mixture is refluxed with stirring for 18 hours. The reaction mixture is concentrated to dryness. The residue is recrystallized from DMF to give ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate (20 g). M.p. 209°-211° C.

후처리

  1. temperaturethe mixture is refluxed
  2. concentrationThe reaction mixture is concentrated to dryness
  3. customThe residue is recrystallized from DMF

출처 및 근거

ORD 기록
ord-c6b4e61da94b46858d0e79b139946c45
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666915

반응 노트

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