HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Butoxyaniline → Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Butoxyaniline | HCID 138265 | — |
| Reactant | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate | HCID 13562779 | 60.1% |
Reaction Steps
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (21.5 g) and 2-butoxyaniline (24 g) are added to pyridine (50 ml), and the mixture is refluxed with stirring for 18 hours. The reaction mixture is concentrated to dryness. The residue is recrystallized from DMF to give ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate (20 g). M.p. 209°-211° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666915 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-c6b4e61da94b46858d0e79b139946c45 |
| Source note | uspto-grants-1987_05 |