HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethyl-p-phenylenediamine → ethyl 1,6-dihydro-2-[4-(N,N-dimethylamino)anilino]-6-oxo-5-pyrimidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethyl-p-phenylenediamine | HCID 7472 | — |
| Reactant | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 1,6-dihydro-2-[4-(N,N-dimethylamino)anilino]-6-oxo-5-pyrimidinecarboxylate | HCID 13562809 | 55.6% |
Reaction Steps
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (20 g) and 4-(N,N-dimethylamino)aniline (19 g) are added to ethanol (200 ml), and the mixture is refluxed with stirring for 19 hours. After cooling, the precipitate is collected by filtration and recrystallized from a mixture of DMF and water to give ethyl 1,6-dihydro-2-[4-(N,N-dimethylamino)anilino]-6-oxo-5-pyrimidinecarboxylate (15.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666915 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-5ed1779484844f8692349d45d4d0f999 |
| Source note | uspto-grants-1987_05 |