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HRID979118

反应详情

EQUATION

反应方程式

HRID 979118 的结构方程式

REACTANTS

反应物

2
结构：CN(C)c1ccc(N)cc1
HCID7472

N,N-Dimethyl-p-phenylenediamine

C8H12N2

结构：CCOC(=O)c1cnc(SC)[nH]c1=O
HCID239049

Ethyl 2-(methylsulfanyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

C8H10N2O3S

PRODUCTS

生成物

1
结构：CCOC(=O)c1cnc(Nc2ccc(N(C)C)cc2)[nH]c1=O
HCID13562809

未命名化合物

收率 55.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (20 g) and 4-(N,N-dimethylamino)aniline (19 g) are added to ethanol (200 ml), and the mixture is refluxed with stirring for 19 hours. After cooling, the precipitate is collected by filtration and recrystallized from a mixture of DMF and water to give ethyl 1,6-dihydro-2-[4-(N,N-dimethylamino)anilino]-6-oxo-5-pyrimidinecarboxylate (15.7 g).

WORKUP

后处理

  1. temperaturethe mixture is refluxed
  2. temperatureAfter cooling
  3. filtrationthe precipitate is collected by filtration
  4. customrecrystallized from a mixture of DMF and water