Ethanol → HCID 23692304, compound

HRID 979137Notes

Reaction equation

HRID 979137 reaction equation
C(=O)([O-])O.[Na+:5].[O:6]=[C:7]1[NH:12][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)=[N:10][CH:9]=[C:8]1[C:24]([OH:26])=[O:25].C(O)C>O>[O:6]=[C:7]1[NH:12][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:22])([F:23])[F:21])[CH:15]=2)=[N:10][CH:9]=[C:8]1[C:24]([O-:26])=[O:25].[Na+:5]

Participants

5

Reactant 3

HCID 702EthanolHCID 516892Sodium BicarbonateHCID 13562849HCID 13562849, compound

Product 1

HCID 23692304HCID 23692304, compoundYield 76.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium hydrogen carbonate (0.82 g) is dissolved in water (50 ml), and thereto is added 1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid (3 g), and the mixture is heated. After foaming is finished, ethanol is added to the reaction mixture, and the solution is allowed to stand overnight. The precipitate is collected by filtration and recrystallized from a mixture of methanol and water to give sodium 1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylate (2.4 g). M.p. 256°-259° C.

Workup

  1. temperaturethe mixture is heated
  2. filtrationThe precipitate is collected by filtration
  3. customrecrystallized from a mixture of methanol and water

Sources & evidence

ORD record
ord-556e87c3cfbb4b2cb6739f21df368d13
Source dataset
uspto-grants-1987_05
Patent number
US04666915

Reaction notes

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