4-Aminophenol → HCID 4131718, compound

HRID 979175Notes

Reaction equation

HRID 979175 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1.[CH:12]1[C:17]([NH2:18])=[CH:16][CH:15]=[C:14]([OH:19])[CH:13]=1>C(O)C>[OH:19][C:14]1[CH:15]=[CH:16][C:17]([NH:18][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[N:4][N:3]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 4034-AminophenolHCID 1607931-Chlorophthalazine

Product 1

HCID 4131718HCID 4131718, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This example describes the synthesis of a compound having the formula ##STR62## A mixture of 2.00 g (12.1 mmol) of 1-chlorophthalazine and 2.64 g (24.2 mmol) of p-aminophenol in 40 ml of absolute ethanol was heated to reflux for 2 h. The precipitate was collected and successively washed with a saturated solution of NaHCO3 and water. The product was crystallized from methanol: mp 245°-247° C. The HCl salt had a mp>300° C.; the IR and NMR spectra were consistent with the assigned structure and the elemental analysis was consistent with the empirical formula (C14H11N3O.HCl).

Workup

  1. customthe synthesis of a compound
  2. temperaturewas heated
  3. temperatureto reflux for 2 h
  4. customThe precipitate was collected
  5. washsuccessively washed with a saturated solution of NaHCO3 and water
  6. customThe product was crystallized from methanol

Sources & evidence

ORD record
ord-20292e79c08644deb754d53109d19118
Source dataset
uspto-grants-1987_05
Patent number
US04666924

Reaction notes

Loading…