Isobutyraldehyde → HCID 53802668, compound

HRID 979186Notes

Reaction equation

HRID 979186 reaction equation
[NH:1]([CH:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5](=[O:13])(=[O:12])[NH:4]1)[NH2:2].[CH:14](=O)[CH:15]([CH3:17])[CH3:16]>O1CCOCC1>[CH:14](=[N:2][NH:1][C:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5](=[O:13])(=[O:12])[N:4]=1)[CH:15]([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 6561IsobutyraldehydeHCID 20201759HCID 20201759, compound

Product 1

HCID 53802668HCID 53802668, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

19.7 g (0.1 mol) of 3-hydrazino-2H,3H-1,2-benzisothiazole 1,1-dioxide are dissolved in 200 ml of dioxane at 40°-50° C., and 8 g (0.11 mol) of isobutyraldehyde are added dropwise to the thoroughly stirred mixture. The product is precipitated directly during this procedure. When the addition is complete, the mixture is heated to 80°-90° C. for about 20 minutes and then cooled, and the crystals are filtered off under suction. 22.1 g (88.1% of theory) of 3-isobutylidenehydrazino-1,2-benzisothiazole 1,1-dioxide of melting point 225° C. are obtained in this manner.

Workup

  1. customThe product is precipitated directly during this procedure
  2. additionWhen the addition
  3. temperaturethe mixture is heated to 80°-90° C. for about 20 minutes
  4. temperaturecooled
  5. filtrationthe crystals are filtered off under suction

Sources & evidence

ORD record
ord-b6a97ba03efb4d65aa5e2f4ce57715c2
Source dataset
uspto-grants-1987_05
Patent number
US04666930

Reaction notes

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