Chlorosulfonic acid → HCID 20201784, compound

HRID 979204Notes

Reaction equation

HRID 979204 reaction equation
[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2].[Cl:24][S:25](O)(=[O:27])=[O:26]>>[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)=[CH:11][CH:10]=[C:9]([S:25]([Cl:24])(=[O:27])=[O:26])[C:7]=2[CH:8]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 20201776HCID 20201776, compound

Product 1

HCID 20201784HCID 20201784, compound

Procedure

2-Acetyl-7-p-nitrobenzyloxybenzofuran (3 g) was added to chlorosulfonic acid at -15° C. for 30 minutes. After the reaction mixture was stirred at -10° to -5° C. for 1 hour, the resultant was gradually added dropwise to ice-water. The solution was extracted with ethyl acetate, washed with water and dried, ethyl acetate being distilled away under reduced pressure to give 2.7 g of crude 2-acetyl-4-chlorosulfonyl-7-p-nitrobenzyloxybenzofuran.

Workup

  1. extractionThe solution was extracted with ethyl acetate
  2. washwashed with water
  3. customdried
  4. distillationethyl acetate being distilled away under reduced pressure

Sources & evidence

ORD record
ord-a23f2e1896044f14931218ec255aa94c
Source dataset
uspto-grants-1987_05
Patent number
US04666931

Reaction notes

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