Chlorosulfonic acid → HCID 20201784, compound

Participants

Reaction Steps

2-Acetyl-7-p-nitrobenzyloxybenzofuran (3 g) was added to chlorosulfonic acid at -15° C. for 30 minutes. After the reaction mixture was stirred at -10° to -5° C. for 1 hour, the resultant was gradually added dropwise to ice-water. The solution was extracted with ethyl acetate, washed with water and dried, ethyl acetate being distilled away under reduced pressure to give 2.7 g of crude 2-acetyl-4-chlorosulfonyl-7-p-nitrobenzyloxybenzofuran.

Provenance & Evidence