HCID 53648267, compound → HCID 20201859, compound

HRID 979229Notes

Reaction equation

HRID 979229 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:6][CH3:7])[CH3:2].[H][H]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:18])[CH:5]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=1)[CH2:6][CH3:7])[CH3:2]

Participants

5

Reactant 2

HCID 53648267HCID 53648267, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20201859HCID 20201859, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

28 g of 2-(p-nitrobenzyl)-butyric acid ethyl ester are dissolved in 200 ml ethyl acetate. The solution is added with 1 g of 10% Pd/C and hydrogenated in a Parr apparatus until complete absorption of hydrogen. After filtering and evaporation from solvent about 25 g of product are obtained as a sufficiently pure oil for the successive reactions.

Workup

  1. filtrationAfter filtering
  2. customevaporation from solvent about 25 g of product
  3. customare obtained as a sufficiently pure oil for the successive reactions

Sources & evidence

ORD record
ord-f6262d0943234b41b0c183d473b12382
Source dataset
uspto-grants-1987_05
Patent number
US04666936

Reaction notes

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