2,2,2-Trichloroethyl hydrazinecarboxylate → HCID 131715142, compound

HRID 979281Notes

Reaction equation

HRID 979281 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=O)[CH2:3][CH2:4][C:5](=[O:9])[NH:6]OC.[Cl:13][C:14]([Cl:22])([Cl:21])[CH2:15][O:16][C:17]([NH:19][NH2:20])=[O:18]>>[NH2:1][C@H:2]([C:10]([NH:20][NH:19][C:17]([O:16][CH2:15][C:14]([Cl:22])([Cl:21])[Cl:13])=[O:18])=[O:12])[CH2:3][CH2:4][C:5](=[O:9])[NH2:6]

Participants

3

Reactant 2

HCID 136885092,2,2-Trichloroethyl hydrazinecarboxylate2×HCID 87750519HCID 87750519, compound

Product 1

HCID 131715142HCID 131715142, compoundYield 46.4%

Procedure

According to the process of H. Watanabe et al, Chemical Pharmaceutical Bulletin, vol. 22, p. 1889 (1974), 4 g of Gln(OMe) is reacted with 4 g of β,β,β-trichloroethyloxycarbonylhydrazine (hereinafter referred to as "TrocNHNH2 ") to obtain 3 g of GlnNHNH-Troc.

Sources & evidence

ORD record
ord-593b03db55ac414281a9068fb47add93
Source dataset
uspto-grants-1987_05
Patent number
US04667017

Reaction notes

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