Hydrazine hydrate (1:1) → HCID 20202092, compound

HRID 979287Notes

Reaction equation

HRID 979287 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([C:11](=O)[CH2:12][CH:13]([CH3:17])[C:14](O)=[O:15])[S:9][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:20][NH2:21]>>[N:1]1([C:6]2[CH:7]=[C:8]([C:11]3[CH2:12][CH:13]([CH3:17])[C:14](=[O:15])[NH:20][N:21]=3)[S:9][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20202145HCID 20202145, compound

Product 1

HCID 20202092HCID 20202092, compound

Procedure

This product is produced from 4-(imidazol-1-yl)-thiophen-2-aldehyde which is reacted with methacrylo nitrile to yield 4-[4-(imidazol-1-yl)-thien-2-yl]-2-methyl-4-oxo-butyric acid nitrile. This compound is hydrolized to 4-[4-(imidazol-1-yl)-thien-2-yl]-2-methyl-4-oxo-butyric acid and which is subjected to reaction with hydrazine hydrate to yield 4.5-dihydro-6-[4-(imidazol-1-yl)-thien-2-yl]-4-methyl-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-ec4edd186c8c4b3f9542bce532cc02ed
Source dataset
uspto-grants-1987_05
Patent number
US04667033

Reaction notes

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